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Investigación: El Aceite de Coco y las enfermedades neurológicas

Estudios y artículos sobre los efectos del Aceite de Coco, los Ácidos Grasos de cadena media (MCFA) y otros productos asociados en las enfermedades neurológicas incluyendo Alzheimer y Epilepsia

2-Deoxy-D-Glucose Treatment Induces Ketogenesis, Sustains Mitochondrial Function, and Reduces Pathology in Female Mouse Model of Alzheimer’s Disease. PLoS One. 2011; 6(7): e21788. e21788. Published online 2011 July 1. doi: 10.1371/journal.pone.0021788

Caregiver Reports Following Dietary Intervention with Medium Chain Fatty Acids in 60 Persons with Dementia. International Symposium of Dietary Interventions for Epilepsy and Other Neurologic Diseases, Edinburgh, Scotland, October 2010.

Efficacy of dietary treatments for epilepsy. J Hum Nutr Diet. 2010 Apr;23(2):113-9.

Dietary supplementation with medium-chain TAG has long-lasting cognition-enhancing effects in aged dogs. Br J Nutr. 2010 Jun;103(12):1746-54. Epub 2010 Feb 9.

Case Study: Dietary intervention using coconut oil to produce mild ketosis in a 58 year old APOE4+ male with early onset Alzheimer’s disease. 25th International Conference of Alzheimer’s Disease International (ADI), March 10-13, 2010, Greece.

Ketone bodies as a therapeutic for Alzheimer’s disease. Future treatments in Alzheimer’s disease. 25th International Conference of Alzheimer’s Disease International (ADI), March 25 ª 10-13, 2010.

Ketogenic diets: an historical antiepileptic therapy with promising potentialities for the aging brain. Ageing Res Rev. 2010 Jul;9(3):273-9. Epub 2010 Feb 24.

Effect of two medium chain triglycerides-supplemented diets on synaptic morphology in the cerebellar cortex of late-adult rats. Microsc Res Tech. Tech. 2009 Dec;72(12):933-8.

A ketogenic diet increases succinic dehydrogenase (SDH) activity and recovers age-related decrease in numeric density of SDH-positive mitochondria in cerebellar Purkinje cells of late-adult rats. finales de ratas adultas. Micron. 2010 Feb;41(2):143-8. Epub 2009 Oct 8.

Study of the ketogenic agent AC-1202 in mild to moderate Alzheimer’s disease: a randomized, double-blind, placebo-controlled, multicenter trial, Published: 10 August 2009,

Nutrition & Metabolism 2009, 6:31 doi:10.1186/1743-7075-6-31

Dietary enrichment with medium chain triglycerides (AC-1203) elevates polyunsaturated fatty acids in the parietal cortex of aged dogs: decline.Neurochem Res. 2009 Sep;34(9):1619-25. Epub 2009 Mar 20.

Medium-chain fatty acids improve cognitive function in intensively treated type 1 diabetic patients and support in vitro synaptic transmission during acute hypoglycemia. Diabetes. 2009 May;58(5):1237-44. Epub 2009 Feb 17. .

A randomized trial of classical and medium-chain triglyceride ketogenic diets in the treatment of childhood epilepsy . 2009 May;50(5):1109-17. Epub 2008 Nov 19

A randomized trial of classical and medium-chain triglyceride ketogenic diets in the treatment of childhood epilepsy. Epilepsia.  2009 May;50(5):1109-17. Epub 2008 Nov 19.

Hypometabolism as a Therapeutic Target in Alzheimer’s Disease , BMC Neurosci. 2008; 9 (Suppl 2): S16.

Induction of ketosis may improve mitochondrial function and decrease steady-state amyloid-beta precursor protein (APP) levels in the aged dog.  Brain Res. 2008 Aug 21;1226:209-17.

Ketone bodies as a therapeutic for Alzheimer’s disease. Neurotherapeutics. 2008 Jul;5(3):470-80.

Medium-chain triglyceride (MCT) ketogenic therapy. Epilepsia. 2008 Nov;49 Suppl 8:33-6.

Direct assessments of the antioxidant effects of propofol medium chain triglyceride/long chain triglyceride on the brain of stroke-prone spontaneously hypertensive rats using electron spin resonance spectroscopy. Anesthesiology. 2008 Sep;109(3):426-35.

Induction of ketosis may improve mitochondrial function and decrease steady-state amyloid-beta precursor protein (APP) levels in the aged dog. Brain Res. Brain Res. 2008 Aug 21;1226:209-17. Epub 2008 Jun 11

Is the antiepileptic effect of the ketogenic diet due to ketones? Med Hypotheses. 2008;70(3):536-9. Epub 2007 Aug 21.

Ketogenic diets cause opposing changes in synaptic morphology in CA1 hippocampus and dentate gyrus of late-adult rats.  Rejuvenation Res. 2008 Jun;11(3):631-40.

Effects of beta-hydroxybutyrate on cognition in memory-impaired adults. Neurobiol Aging. 2004 Mar;25(3):311-4.

Ketogenic diet—an alternative therapy for epilepsy in adults. Harefuah. 1998 Apr 1;134 (7):529-31, 591

Medical aspects of ketone body metabolism. Clin Invest Med. Med Clin Invest. 1995 Jun;18(3):193-216.

Implementing a ketogenic diet based on medium-chain triglyceride oil in pediatric patients with cancer. J Am Diet Assoc. 1995 Jun;95(6):693-7.

Metabolic effects of three ketogenic diets in the treatment of severe epilepsy. Dev Med Child Neurol. Child Neurol. 1989 Apr;31(2):152-60.

The medium chain triglyceride diet and intractable epilepsy. Arch Dis Child. 1986; 61:1168-1172.

Therapeutic effects of a ketogenic diet in Rett syndrome. Am J Med Genet Suppl. 1986;1:225-46.

Medium chain triglyceride diet in the treatment of intractable childhood epilepsy. Arch Dis Child.1986 Dec;61(12):1168-72.

Ketone body metabolism in the neonate: development and the effect of diet. Fed Proc. Fed. Proc. 1985 1985 Apr;44(7):2359-64.

Preferential utilization of ketone bodies in the brain and lung of newborn rats. Fed Proc. Fed. Proc. 1985 Apr;44(7):2352-8.

Early biochemical and EEG correlates of the ketogenic diet in children with atypical absence epilepsy. Pediatr Neural 1985 Mar-Apr;1(2):104-8.

Medium-chain triglyceride (MCT) diet in intractable seizure disorders. Neurology. 1985 1985 Feb;35(2):237-8.

Monitoring octanoic and decanoic acids in plasma from children with intractable epilepsy treated with medium-chain triglyceride diet. Clin Chem. 1982 Apr;28(4 Pt 1):642-5.

Medium chain triglyceride oil ketogenic diets in the treatment of childhood epilepsy. J Hum Nutr. Nutr. 1978 Apr;32(2):111-6.

Medium-chain triglyceride diet in the treatment of intractable childhood epilepsy. Dev Med Child Neurol. Child Neurol. 1978 Apr;20(2):249-50.

Medium-chain triglycerides in a ketogenic diet. Dev Med Child Neurol. 1977 1977 Aug;19(4):535-8.

Ketonemia and seizures: metabolic and anticonvulsant effects of two ketogenic diets in childhood epilepsy. Pediatr Res. 1976 May;10(5):536-40.

Ketogenic diet containing medium-chain triglycerides. J Am Diet Assoc. 1973 1973 Mar;62(3):285-90.

Medium-chain triglycerides as a therapy for intractable childhood epilepsy. Neurology. Neurología. 1971 Nov;21(11):1097-103.